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Abstract #5124

Chemical exchange saturation transfer magnetic resonance imaging of functionalized poly(N, N’-methylene bisacrylamide 4-aminobutanol) gel

Weiqiang Dou1, Jos M.J. Paulusse2, Heinz Peter Janke3, Xiaolei Song4, Jiadi Xu4, J.W.M Bulte4, and Arend Heerschap1

1Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, Netherlands, 2Biomaterials Science and Technology, University of Twente, Enschede, Netherlands, 3Experimental Urology, Radboud University Medical Center, Nijmegen, Netherlands, 4Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Poly (amido amine)s like poly(N, N’-methylene bisacrylamide 4-aminobutanol) (MBA-ABOL) are compounds with promising biomedical applications, which, however, require that they can be visualized without contrast application. In this study we investigated if they can be imaged in a “label free fashion” by CEST MRI making use of their exchangeable amide and hydroxyl protons. We systematically determined optimal conditions for CEST in MBA-ABOL in solution and then demonstrated that the material can be imaged both in vitro and ex vivo, implanted in a rat leg, with a strong CEST effect from the amide protons and substantial effect from the hydroxyl protons.

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