Abstract #5124

Chemical exchange saturation transfer magnetic resonance imaging of functionalized poly(N, N’-methylene bisacrylamide 4-aminobutanol) gel

Weiqiang Dou¹, Jos M.J. Paulusse², Heinz Peter Janke³, Xiaolei Song⁴, Jiadi Xu⁴, J.W.M Bulte⁴, and Arend Heerschap¹

¹Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, Netherlands, ²Biomaterials Science and Technology, University of Twente, Enschede, Netherlands, ³Experimental Urology, Radboud University Medical Center, Nijmegen, Netherlands, ⁴Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Poly (amido amine)s like poly(N, N’-methylene bisacrylamide 4-aminobutanol) (MBA-ABOL) are compounds with promising biomedical applications, which, however, require that they can be visualized without contrast application. In this study we investigated if they can be imaged in a “label free fashion” by CEST MRI making use of their exchangeable amide and hydroxyl protons. We systematically determined optimal conditions for CEST in MBA-ABOL in solution and then demonstrated that the material can be imaged both in vitro and ex vivo, implanted in a rat leg, with a strong CEST effect from the amide protons and substantial effect from the hydroxyl protons.

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