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Abstract #5125

Clinically Feasible Model-based Analysis of Amide Proton Transfer MRI in Acute Ischaemic Stroke

Paula L. Croal1, Yunus Msayib1, Kevin J. Ray2,3, James R. Larkin2, Brad A. Sutherland4,5, George Harston4, Alistair Buchan4, Peter Jezzard3, James Kennedy4, Nicola Sibson2, and Michael Chappell1

1Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, 2CRUK & MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom, 3Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 4Acute Stroke Programme, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, 5School of Medicine, Faculty of Health, University of Tasmania, Hobart, Australia

Model-based analysis of CEST MRI is a robust quantitative method, however, the lengthy acquisition and processing times make it less clinically feasible. It has recently been proposed that partial acquisition of Z-spectra provides a faster approach, but at the cost of increased variability and large alterations in baseline Amide Proton Transfer (APT) effect. Here we present a refined approach, accounting for magnetisation transfer effects, which reduces acquisition and processing times and also decreases variability in the data. We demonstrate its ability to detect pathological reductions in the APT effect in both preclinical and clinical cohorts of acute ischaemic stroke respectively.

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