Model-based analysis of CEST MRI is a robust quantitative method, however, the lengthy acquisition and processing times make it less clinically feasible. It has recently been proposed that partial acquisition of Z-spectra provides a faster approach, but at the cost of increased variability and large alterations in baseline Amide Proton Transfer (APT) effect. Here we present a refined approach, accounting for magnetisation transfer effects, which reduces acquisition and processing times and also decreases variability in the data. We demonstrate its ability to detect pathological reductions in the APT effect in both preclinical and clinical cohorts of acute ischaemic stroke respectively.
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