Quantification of in vivo APT effect with routine asymmetry analysis is problematic due to concomitant contributions. Herein, a steady-state CEST signal solution was utilized to estimate direct water saturation (DWS) to improve Z-spectral quantification in a pulsed-RF CEST imaging. Specifically, APT effect was measured from the DWS and magnetization transfer (MT)-corrected CEST signals in glioma rat brains post-chemoradiotherapy at 3 Tesla. The proposed method revealed significant APT signal difference among regions of control (3.13±0.38%), necrosis (3.95±0.31%) and tumor (4.56±0.34%), consistent with histological observations and superior than routine asymmetry analysis.
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