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Abstract #5126

Improved quantification of amide proton transfer effect with direct water saturation- and magnetization transfer-correction in a glioma rat model at 3 Tesla

Yin Wu1, Yinsheng Chen2, Yiying Zhao2, Shasha Yang1, Jing Zhao1, Zhongping Chen2, and Phillip Zhe Sun3

1Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2Department of Neurosurgery, Cancer Center, Sun Yat-Sen University, Guangzhou, China, 3Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States

Quantification of in vivo APT effect with routine asymmetry analysis is problematic due to concomitant contributions. Herein, a steady-state CEST signal solution was utilized to estimate direct water saturation (DWS) to improve Z-spectral quantification in a pulsed-RF CEST imaging. Specifically, APT effect was measured from the DWS and magnetization transfer (MT)-corrected CEST signals in glioma rat brains post-chemoradiotherapy at 3 Tesla. The proposed method revealed significant APT signal difference among regions of control (3.13±0.38%), necrosis (3.95±0.31%) and tumor (4.56±0.34%), consistent with histological observations and superior than routine asymmetry analysis.

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