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Abstract #5128

Optimization of overlap-resolved CEST for specific mapping of Glutamate and GABA

Frederico Severo1 and Noam Shemesh1

1Champalimaud Centre for the Unknown, Lisbon, Portugal

Glutamate-CEST (GluCEST) has been recently emerging as a powerful new technique for mapping Glutamate in the brain. A recent development termed overlap-resolved CEST (orCEST) has demonstrated that other metabolites may contaminate GluCEST contrast, and proposed how to resolve the wanted signals; here we optimize orCEST contrast to reflect Glutamate and GABA with very high sensitivity and good specificity. orCEST experiments are optimized on metabolite phantoms, and then are applied in-vivo in the rat. The results are promising for neurotransmitter mapping in-vivo.

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