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Abstract #5130

Altered Microcirculation and Oxygenation of Skeletal muscle in Type 2 Diabetes Mellitus (T2DM) Rhesus Monkeys with Non-contrast MRI Perfusion and Oximetry Techniques

Yushu Chen1, Li Gong2, Yu Zhang1, Wen Zeng2, Jie Zheng3, and Fabao Fao1,2

1West China Hospital, Sichuan University, Sichuan 610041, China;, Chengdu, China, 2Sichuan Primed Bio-Tech Group Co., Ltd., Chengdu, China, Chengdu, China, 3Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA, St. Louis, MO, United States

In this study, the altered microcirculation and oxygenation of skeletal muscle in T2DM rhesus monkeys were evaluated by non-contrast skeletal muscle MR perfusion and oximetry techniques. We found that the perfusion of skeletal muscle decreased, especially in fast-twitch fiber muscles, and with an air-cuff caused muscle hyperemia, the ability to reperfusion in slow-twitch muscle is higher than in fast-twitch muscle. The oxygen extraction fraction of skeletal muscle significantly increased in all skeletal muscle angiosomes. These results suggest the diverse adaptation of slow- and fast-twitch skeletal muscles to T2DM.

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