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Abstract #5163

Sex dependence of age-related vertebral bone marrow PDFF and T2 relaxation time changes in a cohort of nearly 200 subjects using multi-TE single-voxel MR spectroscopy

Jan Syväri1, Stefan Ruschke1, Michael Dieckmeyer1, Daniela Franz1, Hans Hauner2, Jan S Kirschke3, Thomas Baum3, and Dimitrios Karampinos1

1Department of Diagnostic and Interventional Radiology, Technical University of Munich, Munich, Germany, 2Department of Nutritional Medicine, Technical University of Munich, Freising, Germany, 3Department of Diagnostic and Interventional Neuroradiology, Technical University of Munich, Munich, Germany

Fat quantification of vertebral bone marrow (VBM) has been often performed with single-TE MRS. Using MRS the differences in the T2-decay of water and fat is neglected and therefore the extracted fat fraction (FF) measure comprises T2-weighting. The aim of this study was to examine differences between T2-weighted FF and proton density fat fraction (PDFF) using multi-TE single-voxel MRS and to relate the observed differences with changes in T2-relaxation of water with age in 197 subjects. The T2-relaxation of water remained constant in males and showed an age dependence in females resulting in amplified gender differences of T2-weighted FF with age compared to PDFF.

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