Abstract #5164

What is the role of MRS-based bone marrow fatty acid unsaturation level compared to fat fraction in predicting vertebral bone strength?

Michael Dieckmeyer¹, Stefan Ruschke¹, D Anitha², Jan S Kirschke³, Dimitrios C Karampinos¹, Subburaj Karupppasamy², and Thomas Baum³

¹Department of Diagnostic and Interventional Radiology, Technical University Munich, Munich, Germany, ²Engineering Product Development, Singapore University of Technology and Design, Singapore, Singapore, ³Department of Diagnostic and Interventional Neuroradiology, Technical University Munich, Munich, Germany

In addition to bone marrow fat content, bone marrow composition is attracting growing interest as an advanced biomarker in the investigation of osteoporosis and bone metabolism. Finite-element analysis of CT imaging data allows non-invasive assessment of bone fracture risk. The present vertebral specimen study showed that vertebral bone marrow fatty acid unsaturation level (UL) is positively correlated with finite-element analysis based failure load and confirmed the negative correlation between bone marrow fat fraction and failure load. However, UL estimation did not improve failure load prediction beyond bone marrow fat fraction in this in-vitro study.

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