Abstract #5170

Texture Analysis of Apparent Diffusion Coefficient (ADC) Maps of Vertebral Bone Marrow in Patients with Multiple Myeloma: Correlation with Clinical Parameters and the Revised International Staging System

Qin Wang¹, Huadan Xue¹, Tianyi Qian², Alto Stemmer³, Shuo Li¹, Zhaoyong Sun¹, and Zhengyu Jin¹

¹Radiology, Peking Union Medical College Hospital, Beijing, China, ²Siemens Healthcare, MR Collaboration NE Asia, Beijing, China, ³Siemens Healthcare, Application Development, Erlangen, Germany

This study aimed to correlate textural parameters derived from apparent diffusion coefficient (ADC) maps of bone marrow to clinical parameters and the revised international staging system (R-ISS) in patients with multiple myeloma (MM). Sixty-one patients with MM underwent whole-body DWI. Texture analysis of ADC maps on vertebral bodies extracted five parameters, including mean, standard deviation, entropy, skewness and kurtosis. These parameters were significantly correlated with clinical parameters of disease burden. Entropy showed the highest diagnostic capacity for discriminating R-ISS stage III from stage I/II. ADC-based textural parameters may serve as adjunct tools for detecting MM patients with advanced R-ISS stages.

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