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Abstract #5169

Texture Analysis Based Separation of Osteosarcoma and Ewing’s Sarcoma using Diffusion Weighted MRI

Esha Baidya Kayal1, Devasenathipathy Kandasamy2, Jayendra Tiru Alampally2, Sameer Bakhshi3, Raju Sharma2, and Amit Mehndiratta1,4

1Centre for Biomedical Engineering, Indian Institute of Technology, Delhi, New Delhi, India, 2Radiodiagnosis, All India Institure of Medical Sciences, New Delhi, New Delhi, India, 3Department of Medical Oncology, IRCH, All India Institure of Medical Sciences, New Delhi, New Delhi, India, 4Department of Biomedical Engineering, All India Institute of Medical Sciences, New Delhi, New Delhi, India

Osteosarcoma(OS) and Ewing’s sarcoma family of tumors(ESFT) are the most common primary malignant bone tumor in children and adolescents. As the patient’s age, presenting signs & symptoms and qualitative imaging features are common in both, there could be a diagnostic dilemma that can only be resolved by biopsy & histopathological assessment. Texture analysis in Diffusion Weighted Imaging(DWI) might provide additional useful information as DWI captures early cellular changes within tumors. We computed textural features in patients with OS and ESFT. Experimental results revealed that textural features provided significant discrimination between OS and ESFT; thus might be useful as diagnostic marker.

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