Abstract #5196

Comparison of gagCEST Effects in Phantoms and Bovine Musculoskeletal Specimens Using 2D Single-Shot Fast Spin Echo and 3D Ultrashort Time-to-Echo at 3-Tesla

Mitsue Miyazaki^1,2, Cheng Ouyang³, Nirusha Abeydeera^1,4, Dawn Berkeley⁵, Reni Biswas^1,4, Sheronda Statum^1,4, Won C Bae^1,4, and Christine B Chung^1,4

¹Radiology, UCSD, La Jolla, CA, United States, ²Toshiba Medical Systems, Otawara, Japan, ³Toshiba Medical Research Institute, Vernon Hills, IL, United States, ⁴VA San Diego Healthcare System, San Diego, CA, United States, ⁵Toshiba America Medical Systems, Tustin, CA, United States

3D UTE and 2D single-shot fast spin-echo (SSFSE) gagCEST techniques were used to image varying concentrations of chondroitin sulfate (CS) in long or short T1 solutions. Echo time (TE) in SSFSE and UTE ranged from 10-60 ms, and 0.1-8 ms, respectively. Effect of TE on asymmetric magnetization transfer ratio (MTR_asym) was examined around 1.0 and 3.5 ppm. For long T1 saline phantom, we found a general increase in MTR_asym with concentration, with similar slopes over different TEs, for either technique. For short T1 MnCl2 doped phantom, while UTE could acquire gagCEST signal unlike SSFSE, no consistent trends were found.

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