Abstract #5200

The uncinate fasciculus: hemispheric asymmetries of DTI metrics and curvature mapping

Lia Talozzi^1,2, Claudia Testa^1,2, Stefania Evangelisti^1,2, Lorenzo Cirignotta^1,2, Claudio Bianchini^1,2, Micaela Mitolo^1,2, Paola Fantazzini^3,4, Caterina Tonon^1,2, David Neil Manners^1,2, and Raffaele Lodi^1,2

¹Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy, ²Functional MR Unit, Policlinico S.Orsola-Malpighi, Bologna, Italy, ³Department of Physics and Astronomy, University of Bologna, Bologna, Italy, ⁴Centro Enrico Fermi, Roma, Italy

We reconstructed the uncinate fasciculus bilaterally by probabilistic tractography in a group of 29 healthy subjects, in order to quantitatively investigating hemispheric asymmetries. We evaluated tract volume and DTI metrics. Our tract Laplacian parameterization successfully described curving bundles and allowed the calculation of along-tract measures and curvature mapping. Group variability maps showed a more dorsal route in the left hemisphere, towards the lateral fronto-orbital cortex. We also found a higher fractional anisotropy on the right compared to the left and different tract curvature. These asymmetries could be associated to specific tract functions as semantic and emotional processing, selectively affected in pathologies.

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