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Abstract #5200

The uncinate fasciculus: hemispheric asymmetries of DTI metrics and curvature mapping

Lia Talozzi1,2, Claudia Testa1,2, Stefania Evangelisti1,2, Lorenzo Cirignotta1,2, Claudio Bianchini1,2, Micaela Mitolo1,2, Paola Fantazzini3,4, Caterina Tonon1,2, David Neil Manners1,2, and Raffaele Lodi1,2

1Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy, 2Functional MR Unit, Policlinico S.Orsola-Malpighi, Bologna, Italy, 3Department of Physics and Astronomy, University of Bologna, Bologna, Italy, 4Centro Enrico Fermi, Roma, Italy

We reconstructed the uncinate fasciculus bilaterally by probabilistic tractography in a group of 29 healthy subjects, in order to quantitatively investigating hemispheric asymmetries. We evaluated tract volume and DTI metrics. Our tract Laplacian parameterization successfully described curving bundles and allowed the calculation of along-tract measures and curvature mapping. Group variability maps showed a more dorsal route in the left hemisphere, towards the lateral fronto-orbital cortex. We also found a higher fractional anisotropy on the right compared to the left and different tract curvature. These asymmetries could be associated to specific tract functions as semantic and emotional processing, selectively affected in pathologies.

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