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Abstract #5201

Ischemic optic neuropathy: Using Track-Weighted Imaging to detect changes in the neuroretina

Arnaud AttyƩ1, Felix Renard1, Clement Jean1, Laurent Lamalle2, and Alexandre Krainik1

1Grenoble University Hospital, Grenoble, France, 2Inserm US 17 - CNRS UMS 3552 - Univ. Grenoble Alpes & CHU Grenoble Alpes, UMS IRMaGe, Grenoble, France

Track-Weighted Imaging was recently introduced as a qualitative tractography-based method with super-resolution properties and high anatomical contrast. We report the use of this method to explore the human retina. In healthy volunteers, we showed that reconstructions of neuroretinal fascicles were influenced by diffusion acquisition parameters, ocular laterality, and ocular dominance. We have raised the hypothesis that patients with anterior ischaemic optic neuropathy, a disease that leads to degeneration of neuroretinal cells, could present with specific neuroretinal fascicle injuries. We demonstrated that presence of the temporal fascicle in the affected eye provides an objective outcome radiological sign correlated with visual recovery.

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