Abstract #5232

Microscopic diffusion anisotropy imaging in the kidneys

Fabio Nery¹, Matt G Hall¹, David L Thomas², Enrico Kaden³, Filip Szczepankiewicz^4,5, Isky Gordon¹, and Chris A Clark¹

¹Developmental Imaging and Biophysics Section, UCL Great Ormond Street Institute of Child Health, London, United Kingdom, ²UCL Institute of Neurology, Department of Brain Repair and Rehabilitation, London, United Kingdom, ³Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, ⁴Clinical Sciences, Lund, Lund University, Lund, Sweden, ⁵Random Walk Imaging AB, Lund, Sweden

Diffusion tensor imaging (DTI) is a widely used diffusion weighted imaging (DWI) approach, successful owing to its sensitivity to changes in tissue microstructure. Recent advances in diffusion MRI acquisition using arbitrary b-tensor shapes allow the in-vivo estimation of tissue microscopic fractional anisotropy (μFA), which unlike conventional fractional anisotropy (FA) is not confounded by orientation dispersion. The aim of this work is to investigate, for the first time, the feasibility of μFA quantification in the kidneys of healthy volunteers.

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