Abstract #5254

Characterization of white matter structures growth in common marmosets

Fumiko Seki^1,2,3, Keigo Hikishima^1,2,4, Yuji Komaki^1,2, Marin Nishio^1,2,5, Junichi Hata^1,2,3, Akiko Uematsu^1,2,3, Norio Okahara², Erika Sasaki^1,2, and Hideyuki Okano^1,3

¹Department of Physiology, Keio University, Tokyo, Japan, ²Central Institute for Experimental Animals, Kawasaki, Japan, ³Laboratory for Marmoset Neural Architecture, Brain Science Institute RIKEN, Saitama, Japan, ⁴Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan, ⁵Department of Radiological Sciences, Tokyo Metropolitan University, Tokyo, Japan

This study investigated developmental patterns of white matter structures in common marmosets using DTI and MTR. Longitudinal MRI was performed to 23 marmosets at the age of 1-34 months. Tract-based ROIs were created for assessment of major fiber bundles. Population growth trajectories of association fibers estimated using Gompertz function showed different developmental patterns. As previously reported, inferior longitudinal fasciculus (ILF) showed earlier maturation with slow speed, whereas inferior fronto-occipital fasciculus (IFOF) showed slower maturation with fast speed observed in MTR, RD and FA. It indicates ILF might mature compared with IFOF at birth, which was consistent with human studies.

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