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Abstract #5254

Characterization of white matter structures growth in common marmosets

Fumiko Seki1,2,3, Keigo Hikishima1,2,4, Yuji Komaki1,2, Marin Nishio1,2,5, Junichi Hata1,2,3, Akiko Uematsu1,2,3, Norio Okahara2, Erika Sasaki1,2, and Hideyuki Okano1,3

1Department of Physiology, Keio University, Tokyo, Japan, 2Central Institute for Experimental Animals, Kawasaki, Japan, 3Laboratory for Marmoset Neural Architecture, Brain Science Institute RIKEN, Saitama, Japan, 4Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan, 5Department of Radiological Sciences, Tokyo Metropolitan University, Tokyo, Japan

This study investigated developmental patterns of white matter structures in common marmosets using DTI and MTR. Longitudinal MRI was performed to 23 marmosets at the age of 1-34 months. Tract-based ROIs were created for assessment of major fiber bundles. Population growth trajectories of association fibers estimated using Gompertz function showed different developmental patterns. As previously reported, inferior longitudinal fasciculus (ILF) showed earlier maturation with slow speed, whereas inferior fronto-occipital fasciculus (IFOF) showed slower maturation with fast speed observed in MTR, RD and FA. It indicates ILF might mature compared with IFOF at birth, which was consistent with human studies.

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