Gliomas are characterized by diffuse infiltration, high heterogeneity and poor prognosis. Imaging tumor heterogeneity may improve diagnosis and therapy planning. The Vascular, Extracellular and Restricted Diffusion for Cytometry in Tumors (VERDICT) MRI technique is a multi-compartmental model that exploits tissue microstructure. This preliminary study demonstrated the feasibility of translating VERDICT MRI in human brain imaging to investigate the microstructure of glioma with an abbreviated protocol. We demonstrated that VERDICT-derived cell size does not differ from the measured size on pathological slides and we found clear trends in LGG and HGG that may be useful to better differentiate types of glioma.
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