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Abstract #5256

Microstructure-mesh projection: Combining shape analysis with diffusion MRI models

Kirsten Lynch1, Yonggang Shi1, Arthur Toga1, and Kristi Clark1

1USC Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, United States

The hippocampus is a heterogeneous structure consisting of subfields with distinct cytoarchitectonic and connectivity patterns. In order to capture the complexity of hippocampal structure, we propose a framework that combines the localized specificity of shape analysis with the microstructural sensitivity obtained with diffusion MRI models. The microstructure-mesh projection pipeline projects local model parameters within the hippocampus onto the surface to enable visualization and analysis of regional microstructural features. In a pediatric dataset, regional patterns of microstructural maturation within the hippocampus were observed.

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