In this study, we explored the use of diffusion imaging measures, as possible biomarkers in clinical trials. We examined the association between vascular risk factors and white matter microstructure in normal aging. Consequently, we studied the relationship between composite and individual mid-life vascular risk factors with late-life white matter microstructure in a cohort of cognitively normal women. The results showed no association between composite score and microstructure. However, there was a significant association between systolic blood pressure and white matter microstructure such as the corpus callosum. Future work is needed to understand this relationship and its effect on cognition.