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Abstract #5259

Brain microstructure alterations associated to Alzheimer's disease assessed by diffusion tensor and neurite orientation dispersion and density imaging.

Emma Muñoz-Moreno1, Laura Obrado2, Raúl Tudela3, Xavier López-Gil1, Gemma Piella2, and Guadalupe Soria1

1Experimental 7T MRI Unit, Institut d'Investigacions Biòmediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, 2Dept. of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Spain, 3CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) Group of Biomedical Imaging of the University of Barcelona, Barcelona, Spain

NODDI characterizes neurite orientation dispersion (ODI) and intracellular volume fraction (ICVF), related to neurite density, based on diffusion magnetic resonance imaging. In this study, we have applied NODDI to evaluate excised brains of TgF344-AD, a transgenic rat model of Alzheimer’s disease (AD) and compared them with brains from control rats. Specific brain regions were evaluated: amygdala, caudate putamen, insular cortex and antero-dorsal and posterior hipppocampi. ODI and ICVF shown a different distribution in AD and control rats, with a tendency to higher values in AD, that could not be observed by standard diffusion parameters such as fractional anisotropy (FA).

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