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Abstract #5268

Early Apparent Diffusion Coefficient Deficit Correlates to Final Outcome in Experimental Neonatal Hypoxic Ischemia

Yu-Chieh Jill Kao1,2, Chia-Feng Lu1,3, Chao-Ching Huang4,5, and Cheng-Yu Chen1,2

1Research Center of Translational Image, Teipei Medical University, Taipei, Taiwan, 2Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, 3Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, 4Department of Pediatrics, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, 5Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan

Changes in apparent diffusion coefficient (ADC) at 2 h after hypoxic ischemia (HI) in neonatal rats showed the significant correlation to the final lesion severity. The early ADC deficit appeared within 6 h after HI injury may serve as an index for outcome prediction and the translational evidence to stratify neonates for hypothermia treatment.

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