Abstract #5269

Diffusion Tensor Imaging of Excised Rat Nerve Following Transection and Surgical Repair

Isaac Vicente Manzanera Esteve¹, Angel F Farinas Chopite², Marlieke C Nussenbaum², Alonda C Pollins², Wes P Thayer², Mark D Does³, and Dortch D Richard¹

¹Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, ²Plastic Surgery, Vanderbilt University Medical Center, Nashville, TN, United States, ³Biomedical Engineering - School of Engineering, Vanderbilt University Medical Center, Nashville, TN, United States

Traumatic peripheral nerve injury (TPNI) from crushing and/or transection can lead to nerve degeneration distal to the site of injury and a temporary loss in sensorimotor function. In this study, we present our findings showing how high-resolution DTI and Tractography measurements of traumatic nerve injury in the sciatic nerve region are capable to identify and characterize nerve injury degeneration/regeneration and injury type in rats. Our findings suggest that DTI and Tractography are viable biomarkers of nerve regeneration and can provide with valuable information in the evaluation of therapeutic interventions

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