Abstract #5271

Gray Matter Myelin Alterations in Early and Late Relapsing-Remitting Multiple Sclerosis Evaluated with Quantitative Synthetic Magnetic Resonance Imaging: A Gray-Matter Based Spatial Statistics Analysis

Christina Andica¹, Akifumi Hagiwara^1,2, Keigo Shimoji³, Koji Kamagata¹, Asami Saito¹, Yuki Takenaka^1,4, Tomoko Maekawa^1,2, Saori Koshino^1,2, Ryusuke Irie^1,2, Akihiko Wada¹, Masaaki Hori¹, Kanako K Kumamaru¹, Kanako Sato¹, Kazumasa Yokoyama⁵, Nobutaka Hattori⁵, and Shigeki Aoki¹

¹Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan, ²Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ³Department of Radiology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan, ⁴Department of Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan, ⁵Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan

Our study demonstrated that myelin volume fraction (MVF) and myelin volume (MyV) obtained by a multi-parametric quantitative synthetic MRI might be useful for evaluating gray matter (GM) myelin alterations and for monitoring disease progression in relapsing-remitting multiple sclerosis (RRMS) patients. GM-based spatial statistics analysis demonstrated decreased MVF in limbic, paralimbic, and deep GM areas in the early-RRMS, and in extensive areas of GM in the late-RRMS. In the meanwhile, MyV was found to be decreased in both RRMS groups compared to healthy subjects, with late-RRMS showing the lowest value, and significantly correlated with disease duration.

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