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Abstract #5272

Discriminative Analysis of Regional Evolution of Iron and Myelin/Calcium in Deep Gray Matter of Multiple Sclerosis and Healthy Subjects

Ahmed M. Elkady1, Dana Cobzas1, Hongfu Sun1, Gregg Blevins2, and Alan H Wilman1

1Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, 2Division of Neurology, University of Alberta, Edmonton, AB, Canada

We introduce Discriminative Analysis of Regional Evolution (DARE) of iron and myelin/calcium to assess specific changes in Deep Gray Matter (DGM) of Relapsing-Remitting Multiple Sclerosis (RRMS), Progressive MS (PMS) and corresponding age-matched healthy subjects, which we regress with disease severity. DARE enabled discriminative assessment of longitudinal changes in MS, and demonstrated superior performance compared to conventional bulk analysis. Iron decrease and myelin/calcium increase, and myelin/calcium changes, were the primary drivers of observed MRI longitudinal changes in RRMS and PMS DGM, respectively. Specific DARE measures of MS DGM can be used to predict MS Severity Score, and may reflect complex disease pathology.

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