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Abstract #5273

Surface-based Quantitative Susceptibility Mapping of Cortical Pathology in Multiple Sclerosis

Marco Castellaro1,2, Roberta Magliozzi2,3, Alessandro Palombit1, Stefania Montemezzi4, Francesca Benedetta Pizzini4, Alessandra Bertoldo1, and Massimiliano Calabrese2

1Department of Information Engineering, University of Padova, Padova, Italy, 2Department of Neurological, Biomedical and Movement Sciences, University of Verona, Verona, Italy, 3Faculty of Medicine, Imperial College London, London, United Kingdom, 4University of Verona, Verona, Italy

Multiple Sclerosis has been showed to be characterized by extent cortical sub-pial demyelination and iron alterations. Moreover, a “surface-in” gradient of pathology has been showed to be present in MS. In this study, we used QSM to investigate iron and/or myelin changes in the whole cortex. Moreover, we exploit surface-based methods to clarify the presence of a laminar specific changes in cortical susceptibility of Relapsing-Remitting MS patients.

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