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Abstract #5278

1H MRS study of glutamate excitotoxicity in hypothalamus of early multiple sclerosis patients

Petra Hnilicová1, Ema Kantorová2, Hubert Poláček 3, Štefan Sivák2, Michal Bittšanský1, Kamil Zeleňák4, Egon Kurča2, and Dušan Dobrota 5

1Division of Neurosciences, Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia, 2Clinic of Neurology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia, 3Clinic of Nuclear Medicine, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia, 4Clinic of Radiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia, 5Department of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia

Multiple sclerosis (MS) is considered as an autoimmune disease with expanding axonal and neuronal degeneration in the spinal cord or cerebral cortex during the acute MS phase. The hypothalamus (HYP) is often overlooked yet controls important homeostatic functions. This 1H MRS study performed on 1.5 T MR scanner using 3D CSI with 10×10×12.5 mm3 voxels was focused to altered HYP metabolism in early MS. Considering our results, increased Glx ratios with reduced mIns and tNAA ratios in HYP suggested glutamate excitotoxicity associated with glial activity and neuronal damage. This indicated that HYP plays an important role in early disease evolution.

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