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Abstract #5279

Examining Cortical Thickness Markers in Relapse Remitting Multiple Sclerosis

Geoffrey Ngo1 and Ravi S Menon1,2

1Medical Biophysics, The University of Western Ontario, London, ON, Canada, 2Centre of Functional and Metabolic Mapping, London, ON, Canada

Recent evidence suggests that cortical pathology in Multiple Sclerosis (MS) does not affect all brain regions equally. We aim to investigate regional cortical MS pathology by using cortical thickness measures in a relapsing-remitting group (RRMS). Structural scans from 21 RRMS and 21 controls were processed using Freesurfer to obtain cortical thickness measurements. Group level analysis was performed to investigate the preference of sulcal and gyral thinning. Differences between gyri and sulci thickness between groups were also calculated to see if there was any evidence of cortical-layer specific thinning. Sulcal preference was shown, and no layer specific thinning was observed.

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