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Abstract #5280

Indirect assessment of cerebral metabolism in deep grey matter areas of progressive multiple sclerosis subjects – preliminary results

Andrea Horvath1, Ian Tagge2, Manoj Sammi2, Katherine Powers2, Dennis Bourdette1, Xin Li2, Rebecca Spain1, Charles Springer2, and William Rooney2

1Neurology, OREGON HEALTH & SCIENCE UNIV, Portland, OR, United States, 2Advanced Imaging Research Center, OREGON HEALTH & SCIENCE UNIV, Portland, OR, United States

Mitochondrial injury and impaired metabolic capacity are hypothesized to drive neurodegeneration in multiple sclerosis (MS). Here, we investigate a novel putative marker of tissue metabolic activity, trans-capillary water flux, derived from dynamic contrast enhanced MRI. In this study we compared 23 subjects with progressive MS to 19 healthy controls. We find significantly reduced measures on capillary water flux in MS thalami compared to controls. Implications for use of this new biomarker are discussed.

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