Autopsy studies of white matter lesions in relapsing-remitting multiple sclerosis demonstrate that FLAIR-bright lesions represent a juxtaposition of inflammation, demyelination, axonal injury and gliosis, whereas T1 hypointense lesions represent more severe confluent injury and axonal loss. We used a white matter tract integrity (WMTI) previously validated in cuprizone animal models of demyelination to better characterize specific in vivo microstructure changes associated with graded T1 signal intensity changes in multiple sclerosis lesions.
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