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Abstract #5286

Advanced diffusion MRI characterization of microstructure changes associated with increasing T1 hypointensity in the white matter lesions of relapsing-remitting multiple sclerosis patients.

Timothy M. Shepherd1, Benjamin Ades-aron1, Bettina Conti1, Yvonne Lui1, Dmitry S Novikov1, and Els Fieremans1

1New York University, New York, NY, United States

Autopsy studies of white matter lesions in relapsing-remitting multiple sclerosis demonstrate that FLAIR-bright lesions represent a juxtaposition of inflammation, demyelination, axonal injury and gliosis, whereas T1 hypointense lesions represent more severe confluent injury and axonal loss. We used a white matter tract integrity (WMTI) previously validated in cuprizone animal models of demyelination to better characterize specific in vivo microstructure changes associated with graded T1 signal intensity changes in multiple sclerosis lesions.

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