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Abstract #5287

DTI Analysis in FLAIR-positive Lesions and Normal-Appearing White Matter in Young Adult Multiple Sclerosis Patients

Tao Wang1, Sindhuja Govindarajan2, M. Andrea Parra1, Patricia Stefancin1, Andrew Labella2, Kenneth Wengler2, Chuan Huang1, Xiang He1, Leigh Charvet3, Lauren Krupp3, and Tim Q Duong1

1Radiology, Stony Brook Medicine, Stony Brook, NY, United States, 2Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, 3New York University, New York, NY, United States

Neuroimaging studies showed that there is abundant diffusion tensor imaging (DTI) research that has been done on older multiple sclerosis (MS) patients. By contrast, similar research is relatively sparse in young/pediatric MS patients. Our study is interested in discovering the effects of MS on young adult patients to see whether the same pattern as in older patients appears. Our results suggest that DTI diffusivity data provides insights in the pathophysiology of MS in young adults. Diffusivity data may serve as an imaging biomarker of early disease pathophysiology in MS.

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