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Abstract #5291

Multicenter assessment of focal and diffuse cervical cord MTR abnormalities in early relapsing-remitting multiple sclerosis

Benoit Combès1, Anne Kerbrat1,2, Laureline Monteau3, Jean-Christophe Ferré1,3, Emmanuelle Le Page2, Josefina Maranzano4, Virginie Callot5, Pierre Labauge6, Xavier Ayrignac6, Clarisse Carra Dallière6, Nicolas Menjot de Champfleur6, Jean Pelletier7, Adil Maarouf7, David Brassat8, Jérome de Seze9, Nicolas Collongues9, Francoise Durand Dubief 10, Christian Barillot1, Gilles Edan2, and Elise Bannier1,3

1Univ Rennes, Inria, CNRS, Inserm, IRISA UMR 6074, VISAGES ERL U-1228, F-35000, Rennes, France, 2Neurology department, Rennes University Hospital, Rennes, France, 3Radiology department, Rennes University hospital, Rennes, France, 4MNI, Montréal, Canada, Montreal, QC, Canada, 5CRMBM UMR7339, Aix-Marseille University, CNRS, Marseille, France, 6Montpellier University Hospital, Montpellier, France, 7APHM, La Timone Hospital, Marseille, France, 8Toulouse University Hospital, Toulouse, France, 9Strasbourg University Hospital, Strasbourg, France, 10Lyon University Hospital, Lyon, France

The purpose of this work was to assess the ability of magnetization transfer ratio imaging of the cervical spinal cord to capture relevant differences in the first stage of multiple sclerosis in a multicenter context. For this purpose, we analyzed the MTR values in the lesions, the whole cord and normal-appearing cord from 52 patients in the first 18 months of the disease and from 17 controls. Images were acquired in 5 centers. We showed such measurements were able to capture relevant group differences and displayed slightly higher correlations with patients clinical status than lesion volume.

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