Abstract #5291

Multicenter assessment of focal and diffuse cervical cord MTR abnormalities in early relapsing-remitting multiple sclerosis

Benoit Combès¹, Anne Kerbrat^1,2, Laureline Monteau³, Jean-Christophe Ferré^1,3, Emmanuelle Le Page², Josefina Maranzano⁴, Virginie Callot⁵, Pierre Labauge⁶, Xavier Ayrignac⁶, Clarisse Carra Dallière⁶, Nicolas Menjot de Champfleur⁶, Jean Pelletier⁷, Adil Maarouf⁷, David Brassat⁸, Jérome de Seze⁹, Nicolas Collongues⁹, Francoise Durand Dubief ¹⁰, Christian Barillot¹, Gilles Edan², and Elise Bannier^1,3

¹Univ Rennes, Inria, CNRS, Inserm, IRISA UMR 6074, VISAGES ERL U-1228, F-35000, Rennes, France, ²Neurology department, Rennes University Hospital, Rennes, France, ³Radiology department, Rennes University hospital, Rennes, France, ⁴MNI, Montréal, Canada, Montreal, QC, Canada, ⁵CRMBM UMR7339, Aix-Marseille University, CNRS, Marseille, France, ⁶Montpellier University Hospital, Montpellier, France, ⁷APHM, La Timone Hospital, Marseille, France, ⁸Toulouse University Hospital, Toulouse, France, ⁹Strasbourg University Hospital, Strasbourg, France, ¹⁰Lyon University Hospital, Lyon, France

The purpose of this work was to assess the ability of magnetization transfer ratio imaging of the cervical spinal cord to capture relevant differences in the first stage of multiple sclerosis in a multicenter context. For this purpose, we analyzed the MTR values in the lesions, the whole cord and normal-appearing cord from 52 patients in the first 18 months of the disease and from 17 controls. Images were acquired in 5 centers. We showed such measurements were able to capture relevant group differences and displayed slightly higher correlations with patients clinical status than lesion volume.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.