Identification of MRI biomarkers that predict permanent neurological disability in multiple sclerosis is crucial for assigning patients to correct treatment and for appropriate recruitment of patients for clinical trials. A variety of brain structures and spinal cord have been investigated; however, neither a single structure nor combinations of structures have been routinely used as stable, specific and sensitive biomarkers. Small sample sizes, different MR protocols and segmentation approaches across studies may hamper the identification of such a biomarker. We evaluated global and regional brain volumes and cervical spinal cord volume in a large single-center cohort of multiple sclerosis patients.
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