Abstract #5294

Relationship of spinal cord volume, total and regional brain volumes to disability in a large cohort of multiple sclerosis patients

Michaela Andelova¹, Jan Krasensky², Lukas Sobisek³, Zdenek Seidl², Eliska Kusova², Tomas Uher¹, Eva Havrdova¹, Barbora Benova¹, Bénédicte Maréchal^4,5,6, Tobias Kober^4,5,6, Dana Horakova¹, and Manuela Vaneckova²

¹Department of Neurology and Center of Clinical Neuroscience, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic, ²Department of Radiology, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic, ³Department of Statistics and Probability, University of Economics, Prague, Czech Republic, ⁴Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ⁵Department of Radiology, University Hospital Lausanne (CHUV), Lausanne, Switzerland, ⁶Signal Processing Laboratory (LTS 5), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

Identification of MRI biomarkers that predict permanent neurological disability in multiple sclerosis is crucial for assigning patients to correct treatment and for appropriate recruitment of patients for clinical trials. A variety of brain structures and spinal cord have been investigated; however, neither a single structure nor combinations of structures have been routinely used as stable, specific and sensitive biomarkers. Small sample sizes, different MR protocols and segmentation approaches across studies may hamper the identification of such a biomarker. We evaluated global and regional brain volumes and cervical spinal cord volume in a large single-center cohort of multiple sclerosis patients.

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