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Abstract #5295

Hypersynchronicity in the default mode-like network and altered NMDA receptor function in a maternal immune activation model

Stephan Missault1,2, Cynthia Anckaerts2, Soumaya Ahmadoun1, Ines Blockx2,3, Kenny Bielen4, Disha Shah2, Samir Kumar-Singh4, Annemie Van der Linden2, Stefanie Dedeurwaerdere1, and Marleen Verhoye2

1Translational Neurosciences, University of Antwerp, Wilrijk, Belgium, 2Biomedical Sciences, University of Antwerp, Wilrijk, Belgium, 3Department of Radiology, NYU Langone medical Center, New York, NY, United States, 4Veterinary Sciences, University of Antwerp, Wilrijk, Belgium

Maternal immune activation (MIA) is an important risk factor for schizophrenia, which supports the neurodevelopmental hypothesis of this disorder. Two major hypotheses of schizophrenia are the aberrant connectivity hypothesis and the NMDA receptor hypofunction hypothesis. The goal of our study was to investigate functional and structural connectivity, as well as NMDA receptor function in a MIA model using resting-state functional MRI, diffusion tensor imaging and pharmacological MRI. We observed increased functional connectivity in the default mode-like network, as well as a decreased response to the NMDA receptor antagonist in adult rats that were exposed to prenatal immune challenge.

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