Abstract #5295

Hypersynchronicity in the default mode-like network and altered NMDA receptor function in a maternal immune activation model

Stephan Missault^1,2, Cynthia Anckaerts², Soumaya Ahmadoun¹, Ines Blockx^2,3, Kenny Bielen⁴, Disha Shah², Samir Kumar-Singh⁴, Annemie Van der Linden², Stefanie Dedeurwaerdere¹, and Marleen Verhoye²

¹Translational Neurosciences, University of Antwerp, Wilrijk, Belgium, ²Biomedical Sciences, University of Antwerp, Wilrijk, Belgium, ³Department of Radiology, NYU Langone medical Center, New York, NY, United States, ⁴Veterinary Sciences, University of Antwerp, Wilrijk, Belgium

Maternal immune activation (MIA) is an important risk factor for schizophrenia, which supports the neurodevelopmental hypothesis of this disorder. Two major hypotheses of schizophrenia are the aberrant connectivity hypothesis and the NMDA receptor hypofunction hypothesis. The goal of our study was to investigate functional and structural connectivity, as well as NMDA receptor function in a MIA model using resting-state functional MRI, diffusion tensor imaging and pharmacological MRI. We observed increased functional connectivity in the default mode-like network, as well as a decreased response to the NMDA receptor antagonist in adult rats that were exposed to prenatal immune challenge.

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