Meeting Banner
Abstract #5297

Ex-vivo diffusion MRI reveals microstructural alterations in stress-sensitive brain regions: A chronic mild stress recovery study

Ahmad Raza Khan1, Brian Hansen1, Ove Wiborg1, Christopher D Kroenke2, and Sune Nørhøj Jespersen1,3

1Clinical Medicine, Aarhus University, Aarhus C, Denmark, 2Oregon Health and Science University, Portland, OR, United States, 3Dept. of Physics and Astronomy, Aarhus University, Aarhus, Denmark

Depression is a leading cause of disability worldwide and causes significant microstructural alterations in stress-sensitive brain regions. However, the potential recovery of these microstructural alterations has not previously been investigated, which we, therefore, set out to do using diffusion MRI (d-MRI) in the chronic mild stress (CMS) rat model of depression. This study reveals significant microstructural alterations after 8 weeks of recovery, in the opposite direction to change induced by stress in the acute phase of the experiment. Such findings may be useful in the prognosis of depression or for monitoring treatment response.

This abstract and the presentation materials are available to members only; a login is required.

Join Here