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Abstract #5298

Analysis of resting-state networks alterations of first-episode obsessive–compulsive disorder by ICA -based fMRI

Junhong Liu1, Dandan Zheng2, and Jingliang Cheng3

1Magnetic resonance imaging Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou City, China, 2GE Healthcare, MR Research China, Zhengzhou, China, 3The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

Whole brain resting-state functional connectivity was analyzed using independent component analysis in 47 subjects including 23 first-episode and treatment-naïve patients with obsessive-compulsive disorder(OCD) and 24 health controls. Three abnormal resting-state networks, pDMN, RFP and lVN, have been found in OCD patients. In addition, OCD patients showed increased functional connection in Bilateral cuneus(T=3.8222,P=0.005), Right inferior parietal lobule(T=5.291,P=0.005)and Right middle occipital lobule(T=4.614,P=0.005) compared with controls. It’s considered that changes of abnormal resting-state networks might be associated with emotional and cognitive dysfunction in OCD patients.

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