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Abstract #5299

Disrupted reward and cognitive control networks contribute to anhedonia in depression

Liang Gong1, Chunming Xie2, Hongxing Zhang3, and Zhijun Zhang4

1Neurology, Southeast Uninversity, Nanjing, China, 2Neurology, Southeast University, Nanjing, China, 3Xinxiang Medical Colleage, Xinxiang, China, 4Southeast University, Nanjing, China

In the present study, we investigate the association between intrinsic reward network (β-network) and cognitive control network (δ-network) and anhedonia in depression patient. We found that depression patients showed decreased functional connectivity (FC) in intra- and inter- β- and δ-networks and the FC in both β- and δ-networks were significantly correlated with anhedonic severity in depression patients. Importantly, the integrated neural features of β- and δ-networks would more precisely predict anhedonia symptom. These findings indicated that the neural features in both β- and δ-networks would represent a fundamental mechanism underlying anhedonia in the MDD patients.

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