Electroconvulsive therapy is a safe, rapid-acting antidepressant treatment that has consistently been associated with grey matter (GM) volume increase, primarily in the medial temporal lobe (MTL). Here we replicate and extend previous studies by demonstrating substantial surface area and local displacement changes in subcortical and MTL GM one week following the last ECT treatment in 70 patients with late-life depression. We report new data on ECT induced thalamus shape changes, and demonstrate that whilst the number of ECT treatments correlates positively with the degree of medial temporal GM surface area increase, this is not associated with clinical improvement in mood.
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