Abstract #5301

Reduced White Matter Integrity Related with Elevated Inﬂammatory Cytokine Expression and Cognitive Impairments in First-episode Schizophrenia: A Diffusion Tensor Imaging Study Based on Tract-Based Spatial Statistics

Jie Gao¹, Yajuan Fan², Lei Wang³, Yarong Wang³, Feng Zhu², Min Tang¹, Dongsheng Zhang¹, Xia Zhe¹, Xuejiao Yan¹, Xin Zhang¹, Zhizheng Zhuo⁴, and Xiaoling Zhang¹

¹Department of MRI Diagnosis, Shannxi Provincial People's Hospital, Xi'an, China, ²Department of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China, ³Department of Diagnostic Radiology, The First Affiliated Hospital, Xi’an Jiaotong University, Xi'an, China, ⁴Philips Healthcare, Beijing, China

This study aimed to investigate whether elevated inﬂammatory cytokine expression induced white matter integrity changes and cognitive impairments in first-episode schizophrenia patients. 27 first-episode schizophrenia patients and 16 healthy controls who underwent diffusion tensor imaging were enrolled. Tract-based spatial statistics analysis exhibited significantly decreased fractional anisotropy and increased radial diffusivity in widespread white matter tracts in patients. Of these tracts, anterior corona radiata (ACR), superior corona radiata, superior longitudinal fasciculus, the body of the corpus callosum, the splenium of the corpus callosum and fornix showed signiﬁcant correlations with higher inﬂammatory cytokine expression. Moreover, ACR and fornix simultaneously showed reduced white matter integrity related to cognitive impairments in working memory and problem solving. These findings provides more evidence for supporting the role of neuroinﬂammation in the pathophysiology of schizophrenia.

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