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Abstract #5301

Reduced White Matter Integrity Related with Elevated Inflammatory Cytokine Expression and Cognitive Impairments in First-episode Schizophrenia: A Diffusion Tensor Imaging Study Based on Tract-Based Spatial Statistics

Jie Gao1, Yajuan Fan2, Lei Wang3, Yarong Wang3, Feng Zhu2, Min Tang1, Dongsheng Zhang1, Xia Zhe1, Xuejiao Yan1, Xin Zhang1, Zhizheng Zhuo4, and Xiaoling Zhang1

1Department of MRI Diagnosis, Shannxi Provincial People's Hospital, Xi'an, China, 2Department of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China, 3Department of Diagnostic Radiology, The First Affiliated Hospital, Xi’an Jiaotong University, Xi'an, China, 4Philips Healthcare, Beijing, China

This study aimed to investigate whether elevated inflammatory cytokine expression induced white matter integrity changes and cognitive impairments in first-episode schizophrenia patients. 27 first-episode schizophrenia patients and 16 healthy controls who underwent diffusion tensor imaging were enrolled. Tract-based spatial statistics analysis exhibited significantly decreased fractional anisotropy and increased radial diffusivity in widespread white matter tracts in patients. Of these tracts, anterior corona radiata (ACR), superior corona radiata, superior longitudinal fasciculus, the body of the corpus callosum, the splenium of the corpus callosum and fornix showed significant correlations with higher inflammatory cytokine expression. Moreover, ACR and fornix simultaneously showed reduced white matter integrity related to cognitive impairments in working memory and problem solving. These findings provides more evidence for supporting the role of neuroinflammation in the pathophysiology of schizophrenia.

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