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Abstract #5303

Investigation of Schizophrenia Patients with Clozapine-Induced Obsessive Compulsive Symptoms by Advanced MR Imaging

Arzu Ceylan Has1, Sule Bicakci2, Elif Bulut3, Aygun Ertugrul2, and Kader K. Oguz3

1National Magnetic Resonance Research Center (UMRAM), Bilkent University, Ankara, Turkey, 2Department of Neurological Sciences and Psychiatry, Hacettepe University, Ankara, Turkey, 3Department of Radiology, Hacettepe University, Ankara, Turkey

We aimed to investigate white matter (WM) integrity and structural differences in schizophrenia patients with clozapine-induced obsessive compulsive symptoms (S-OCS) comparing them those without symptoms (S) and healthy controls (HC). Tract-based-spatial-statistic/diffusion-tensor-imaging, voxel-based morphometry, and caudate volume measurements were performed to reveal underlying WM and gray matter (GM) alterations. S-OCS showed less fractional anisotropy (FA) reductions in WM and less areas of reduced GM density than S when compared to HC. FA elevations and increased GM density were observed in S-OCS compared with S. The results may suggest differential effect of clozapine, and/or different baseline pathophysiology in a subgroup of patients.

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