We aimed to investigate white matter (WM) integrity and structural differences in schizophrenia patients with clozapine-induced obsessive compulsive symptoms (S-OCS) comparing them those without symptoms (S) and healthy controls (HC). Tract-based-spatial-statistic/diffusion-tensor-imaging, voxel-based morphometry, and caudate volume measurements were performed to reveal underlying WM and gray matter (GM) alterations. S-OCS showed less fractional anisotropy (FA) reductions in WM and less areas of reduced GM density than S when compared to HC. FA elevations and increased GM density were observed in S-OCS compared with S. The results may suggest differential effect of clozapine, and/or different baseline pathophysiology in a subgroup of patients.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords