Abstract #5312

Alterations in functional brain network topology in Tourette’s syndrome

Shukti Ramkiran¹, Larissa Heidemeyer², Ravichandran Rajkumar^1,2,3,4, N Jon Shah^1,3,4,5,6,7, and Irene Neuner^1,2,3,4

¹Institute of Neuroscience and Medicine - 4, INM-4, Forschungszentrum Juelich, Juelich, Germany, ²Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany, ³JARA-BRAIN Translational Medicine, Aachen, Germany, ⁴TRIMAGE – consortium, Aachen, Germany, ⁵Institute of Neuroscience and Medicine - 11, INM-11, Forschungszentrum Juelich, Juelich, Germany, ⁶Department of Neurology, RWTH Aachen University, Aachen, Germany, ⁷Department of Electrical and Computer Systems Engineering, and Monash Biomedical Imaging, School of Psychological Sciences, Monash Institute of Medical Engineering, Monash University, Melbourne, Australia

Tourette syndrome (TS) is a neurodevelopmental disorder with typical onset in childhood. Its characteristic motor tics are said to be attributed to dysfunction in the cortico-striato-thalamo-cortical circuit and cerebellar communication. Brain functional connectivity along with network topology analysis provides a useful tool to understand communication strategies in the brain. Hence we aim to investigate alterations in functional and effective connectivity in brains of patients with TS. Based on prior results^1,2, we hypothesize that connectivity of basal ganglia, thalamus and cerebellum with other regions will be altered.

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