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Abstract #5311

Characteristic Changes of Shape in Subcortical Nuclei in Major Depressive Disorder

Lianqing Zhang1, Naici Liu2, Lu Li3, Lu Lu1, Xiaoxiao Hu1, Hailong Li1, Xuan Bu1, Xinyu Hu1, Qiyong Gong1, and Xiaoqi Huang1

1Department of Radiology, West China Hospital of Sichuan University, Huaxi MR Research Center (HMRRC), Chengdu, China, 2Sichuan University, West China School of Clinical Medicine, Chengdu, China, 3Sichuan University, West China School of Public Health, Chengdu, China

We analysis alterations of volume and shape of subcortical nuclei in a relatively large sample of adult patients with Major Depressive Disorder (MDD) using an automatically segmentation and vertex-based shape analysis protocol. We found that hippocampus, putamen and accumbens were impaired in patients with MDD and subregional shape of hippocampus, accumbens and pallidum may have potential predictive value of treatment response in patients with MDD. Shape analysis may provide more evidence of neuropathology related to depression from a different perspective. Future study should consider shape and volume analysis simultaneously.

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