Abstract #5310

The effects of relapse on gray matter volume changes in patients with Major Depression – a longitudinal VBM study

Harald Kugel¹, Dario Zaremba², Katharina Dohm², Ronny Redlich², Dominik Grotegerd², Robert Strojny², Susanne Meinert², Christian Buerger², Verena Enneking², Katharina Foerster², Jonathan Repple², Nils Opel², Bernhard T Baune³, Pienie Zwitserlood⁴, Walter Heindel¹, Volker Arolt², and Udo Dannlowski²

¹Department of Clinical Radiology, University of Muenster, Muenster, Germany, ²Department of Psychiatry, University of Muenster, Muenster, Germany, ³Discipline of Psychiatry, University of Adelaide, Adelaide, Australia, ⁴Department of Psychology, University of Muenster, Muenster, Germany

Structural brain alterations in major depressive disorder (MDD) are associated with patients' course of illness, especially in progressive and recurrent MDD. Here, a longitudinal study investigated the influence of relapse on gray matter volume. As a result, Voxel based morphometry showed a decrease of insular and DLPF gray matter volume in patients with at least one relapse, while volume in patients without relapse was stable. This illustrates the negative effect of relapse on structural brain alterations.

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