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Abstract #5310

The effects of relapse on gray matter volume changes in patients with Major Depression – a longitudinal VBM study

Harald Kugel1, Dario Zaremba2, Katharina Dohm2, Ronny Redlich2, Dominik Grotegerd2, Robert Strojny2, Susanne Meinert2, Christian Buerger2, Verena Enneking2, Katharina Foerster2, Jonathan Repple2, Nils Opel2, Bernhard T Baune3, Pienie Zwitserlood4, Walter Heindel1, Volker Arolt2, and Udo Dannlowski2

1Department of Clinical Radiology, University of Muenster, Muenster, Germany, 2Department of Psychiatry, University of Muenster, Muenster, Germany, 3Discipline of Psychiatry, University of Adelaide, Adelaide, Australia, 4Department of Psychology, University of Muenster, Muenster, Germany

Structural brain alterations in major depressive disorder (MDD) are associated with patients' course of illness, especially in progressive and recurrent MDD. Here, a longitudinal study investigated the influence of relapse on gray matter volume. As a result, Voxel based morphometry showed a decrease of insular and DLPF gray matter volume in patients with at least one relapse, while volume in patients without relapse was stable. This illustrates the negative effect of relapse on structural brain alterations.

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