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Abstract #5309

Quantative Tractography Reveals Alteration in Corticospinal Tract Associated with Motor Abnormalies in Medication-Naive Attention-Deficit /Hyperactivity Disorder Children

Xuan Bu1, Qingxia Lin2, Lu Lu1, Lianqing Zhang1, Xiaoxiao Hu1, Hailong Li1, Xinyu Hu1, Chuang Yang2, and Xiaoqi Huang1

1Huaxi MR Research Center(HMRRC), Radiology Department, West China Hospital, Sichuan University, Chengdu, China, 2Department of Psychiatry, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, China

In the current study, we aim to quantify diffusion measures at multiple nodes along the trajectory of corticospinal tract in ADHD children. We found altered FA and RD in distinctive CST regions. Besides, significant correlations between neuropsychological measurements and abnormal white matter microstructure implicated critical role the disturbed CST played in the pathology of motor deficits in ADHD.

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