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Abstract #5308

A multi-methodological fMRI resting state voxel-wise analysis to assess brain abnormalities of children with ADHD

Yingxue Gao1, Hailong Li1, Xuan Bu1, Lianqing Zhang1, Xinyu Hu1, Peiran Hu2, Xiaoxiao Hu1, and Xiaoqi Huang1

1Huaxi Magnetic Resonance Research Centre (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, 2West China Hospital / West China School of Medicine Sichuan University, Chengdu, China

We used three different measurements including regional homogeneity (ReHo), voxel-mirrored homotopic connectivity (VMHC) and functional connectivity strength (FCS) to explore local and interhemispheric FC in drug naïve ADHD children. And we found lower ReHo and FCS in ADHD located in almost identical region of right middle frontal gyrus and correlated with each other. In addition, we also found lower VMHC in the bilateral occipital lobe, which was related with characteristics of WCST and CPRS-R. This finding may provide new insights into functional connectivity changes in ADHD and promote the exploration of functional network in the future.

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