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Abstract #5307

Multimodal metabolic imaging using single voxel MRS and [11C]ABP688 PET in Schizophrenic Patients

Linda Orth1,2, Ravichandran Rajkumar1,2,3,4, Cláudia Régio Brambilla 1, Ezequiel Farrher1, Andreas Matusch5, Shukti Ramkiran1, Andrej Ruch 2, Jörg Mauler1, Elena Rota Kops1, Lutz Tellmann1, Jürgen Scheins1,4, Bernd Neumaier6, Markus Lang6, Johannes Ermert6, Hans Herzog1, Karl-Josef Langen1,3,7, Christoph Lerche1,4, N. Jon Shah1,3,4,8,9,10, and Irene Neuner1,2,3,4

1Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany, 2Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany, 3JARA – BRAIN – Translational Medicine, Jülich, Germany, 4TRIMAGE – consortium (, Jülich, Germany, 5Institute of Neuroscience and Medicine 2, INM-2, Forschungszentrum Jülich, Jülich, Germany, 6Institute of Neuroscience and Medicine 5, INM-5, Forschungszentrum Jülich, Jülich, Germany, 7Department of Nuclear Medicine, RWTH Aachen University, Aachen, Germany, 8Institute of Neuroscience and Medicine 11, INM-11, Forschungszentrum Jülich, Jülich, Germany, 9Department of Neurology, RWTH Aachen University, Aachen, Germany, 10Monash Biomedical Imaging, School of Psychological Sciences, Monash University, Melbourne, Australia

By utilizing a multimodal imaging approach, the levels of glutamate and other metabolites in the anterior cingulate and the posterior cingulate cortex were assessed by MRS and compared to the metabotropic glutamate receptor 5 (mGluR5) binding potential using [11C]ABP688 PET in schizophrenic patients and healthy controls. Glutamate levels seem to be elevated in schizophrenic patients. PET analysis revealed no differences in binding potential (BPND) in both diagnostic groups. However, adding smoking status to analysis, there is a significant reduction in BPND in smokers compared to non-smokers, suggesting a connection between mGluR5 binding potential and nicotine dependence.

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