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Abstract #5315

Meta-analysis of Resting-State Functional Connectivity in Major Depressive Disorder

Shi Tang1, Xinyu Hu1, Lianqing Zhang1, Lu Lu1, Xuan Bu1, Xiaoxiao Hu1, Hailong Li1, Qiyong Gong1, and Xiaoqi Huang1

137#Guoxue lane, Huaxi Magnet Resonance Imaging(HMRRC),Department of Radiology,West China Medical School of Sichuan University, Chengdu, China

To investigate the most reliable resting-state functional connectivity(rsFC) abnormalities in adult dignosed as having major depressive disorder(MDD) with existing studies.After a comprehensive literature search of studies, meta analysis was conducted using Signed Differential Mapping(SDM) software package. We found dysfunction in large-scale brain regions in MDD patients, including hyperconnectivity in fronto-cingulate-parietal area and hypoconnectivity in bilateral superior temporal gyrus(STG). These findings paralleled to the core feature of MDD patients and may underlie the cognitive and affective abnormalities in depressive disorder.

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