To investigate the gray matter volume (GMV) alteration in major depressive disorder (MDD) patients at different episode state, here we conducted a meta-analysis which tried to integrate the Voxel-based morphometry (VBM) studies by using Seed-based d Mapping. This study detected that lower GMV in the left insula in both current and remitted MDD patients compared to HC. And the current conjunction meta-analysis indicated that GMV in bilateral anterior cingulate (ACC) were decreased in current MDD patients but increased in remitted MDD patients. Our findings here motivate a morphological alteration pattern of MDD linked to dynamic mood dysfunction state.
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