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Abstract #5316

The morphometric brain alteration in current and remitted major depressive disorder: a meta-analysis

Xin Xu1, Zhiyun Jia2, and Qiyong Gong1

1Huaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, Chengdu, China, 2Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, China

To investigate the gray matter volume (GMV) alteration in major depressive disorder (MDD) patients at different episode state, here we conducted a meta-analysis which tried to integrate the Voxel-based morphometry (VBM) studies by using Seed-based d Mapping. This study detected that lower GMV in the left insula in both current and remitted MDD patients compared to HC. And the current conjunction meta-analysis indicated that GMV in bilateral anterior cingulate (ACC) were decreased in current MDD patients but increased in remitted MDD patients. Our findings here motivate a morphological alteration pattern of MDD linked to dynamic mood dysfunction state.

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