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Abstract #5329

Flow-compensated IVIM model: accuracy and precision as function of SNR, b-values and perfusion fraction

Susanne S. Rauh1,2, Oliver J. Gurney-Champion2, Uwe Oelfke2, Frederik B. Laun1, and Andreas Wetscherek2

1Institute of Radiology, University Hospital Erlangen, Erlangen, Germany, 2Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom

To use intravoxel incoherent motion (IVIM) modelling for clinical applications, the model parameters need to be determined accurately and precisely, which was found challenging. We studied the influence of signal-to-noise ratio (SNR), number of b-values and perfusion fraction on the accuracy of the recently introduced flow-compensated IVIM model parameters (tissue diffusivity, perfusion fraction, characteristic timescale and blood flow velocity). Simulations were performed for typical parameters obtained in healthy volunteers for pancreas and kidney and revealed that for an SNR of 20, 9 b-values and a perfusion fraction of more than 15% are needed for reliable parameter estimation in flow-compensated IVIM.

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