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Abstract #5330

Simultaneous IVIM and kurtosis acquisition in brain tumours: a trace-based protocol validated in a hybrid MR-PET system

Ricardo Loução1, Ana-Maria Oros-Peusquens1, Karl-Josef Langen1, Hugo Alexandre Ferreira2, and N. Jon Shah1

1INM4 - FZJ, Jülich, Germany, 2Instituto de Biofísica e Engenharia Biomédica, Sciences Faculty, University of Lisbon, Lisbon, Portugal

Diffusion weighted imaging such as intravoxel incoherent motion (IVIM) and non-Gaussian diffusion (NG-diff) allow the non-invasive study of tissue perfusion and are able to infer the organisation of the microstructure, respectively. Both are highly relevant in pathology characterisation, but are often acquired separately. Here we propose a unified IVIM/NG-diff protocol and apply it to brain tumour patients undergoing preoperative or follow-up scans in a hybrid MR-PET environment. The results agree well with previously reported values using standard techniques. Furthermore, indication for tumour grading power of IVIM parameters was found.

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