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Abstract #5343

A framework for b-value optimization in DWI

Rick Keesman1, Leon ter Beek2, and Uulke van der Heide1

1Department of Radiation Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands, 2Department of Radiology, Netherlands Cancer Institute, Amsterdam, Netherlands

Diffusion-weighted imaging is a valuable asset in the diagnosis of a plethora of diseases. General guidelines are available when measuring (mono-exponential) diffusion in several organs of interest, but there is less consensus on optimal acquisition parameters for more complex models (e.g., intravoxel incoherent motion, kurtosis). We provide a general, easy to implement, solution scheme (similar to the Cramér–Rao lower bound approach) that can be used to optimize the acquisition protocol with respect to the $$$b$$$-values. We present mathematical proof, and phantom as well as in-vivo measurements that corroborate the viability of our method.

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