Abstract #5344

Investigation of the Effect of Body Posture on Dynamic ADC Change during Cardiac Cycle in Human Brain

Naoki Ohno¹, Tosiaki Miyati¹, Masatomo Uehara¹, Yuki Hiramatsu¹, Riho Okamoto¹, Mitsuhito Mase², Satoshi Kobayashi¹, and Toshifumi Gabata¹

¹Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan, ²Department of Neurosurgery, Nagoya City University, Nagoya, Japan

Intracranial conditions are strongly affected by body posture. Apparent diffusion coefficient (ADC) of the brain significantly changes during the cardiac cycle, and this change (ΔADC) reflects intracranial condition. However, the effect of body posture on ΔADC has yet to be confirmed. Therefore, we evaluated the ΔADC and ADC of the brain in upright and supine postures using a multi-posture MRI. ΔADC and ADC of the white matter in the upright posture were significantly higher than those in the supine posture. Multi-posture MRI facilitates the noninvasive evaluation of the effect of gravity on intracranial conditions.

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