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Abstract #5344

Investigation of the Effect of Body Posture on Dynamic ADC Change during Cardiac Cycle in Human Brain

Naoki Ohno1, Tosiaki Miyati1, Masatomo Uehara1, Yuki Hiramatsu1, Riho Okamoto1, Mitsuhito Mase2, Satoshi Kobayashi1, and Toshifumi Gabata1

1Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan, 2Department of Neurosurgery, Nagoya City University, Nagoya, Japan

Intracranial conditions are strongly affected by body posture. Apparent diffusion coefficient (ADC) of the brain significantly changes during the cardiac cycle, and this change (ΔADC) reflects intracranial condition. However, the effect of body posture on ΔADC has yet to be confirmed. Therefore, we evaluated the ΔADC and ADC of the brain in upright and supine postures using a multi-posture MRI. ΔADC and ADC of the white matter in the upright posture were significantly higher than those in the supine posture. Multi-posture MRI facilitates the noninvasive evaluation of the effect of gravity on intracranial conditions.

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