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Abstract #5355

An open-source framework for analysis of multidimensional diffusion MRI data implemented in MATLAB

Markus Nilsson1, Filip Szczepankiewicz1,2, Björn Lampinen3, André Ahlgren3, João P. de Almeida Martins2,4, Samo Lasic2, Carl-Fredrik Westin5, and Daniel Topgaard4

1Clinical Sciences Lund, Radiology, Lund University, Lund, Sweden, 2Random Walk Imaging, Lund, Sweden, 3Clinical Sciences Lund, Medical Radiation Physics, Lund University, Lund, Sweden, 4Department of Chemistry, Physical Chemistry, Lund University, Lund, Sweden, 5Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States

Reproducible research requires robust methods for data management and analysis. We have developed a comprehensive analysis framework for diffusion MRI data based on a robust but flexible management of data and metadata, which enables rapid prototyping and sharing of code. The framework is tailored to deal with multidimensional diffusion MRI data featuring novel types of diffusion encoding strategies, such as b-tensor encoding. It also features routines for higher order tensor mathematics as well as adapted volume registration for motion correction, an analysis GUI and other tools.

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