Abstract #5355

An open-source framework for analysis of multidimensional diffusion MRI data implemented in MATLAB

Markus Nilsson¹, Filip Szczepankiewicz^1,2, Björn Lampinen³, André Ahlgren³, João P. de Almeida Martins^2,4, Samo Lasic², Carl-Fredrik Westin⁵, and Daniel Topgaard⁴

¹Clinical Sciences Lund, Radiology, Lund University, Lund, Sweden, ²Random Walk Imaging, Lund, Sweden, ³Clinical Sciences Lund, Medical Radiation Physics, Lund University, Lund, Sweden, ⁴Department of Chemistry, Physical Chemistry, Lund University, Lund, Sweden, ⁵Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States

Reproducible research requires robust methods for data management and analysis. We have developed a comprehensive analysis framework for diffusion MRI data based on a robust but flexible management of data and metadata, which enables rapid prototyping and sharing of code. The framework is tailored to deal with multidimensional diffusion MRI data featuring novel types of diffusion encoding strategies, such as b-tensor encoding. It also features routines for higher order tensor mathematics as well as adapted volume registration for motion correction, an analysis GUI and other tools.

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